Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.

摘要: Parkinson's disease (PD) is a well-known neurodegenerative with strong association established systemic inflammation. Recently, the role of gingipain protease group from Porphyromonas gingivalis was implicated in Alzheimer's and here we present evidence, using fluorescent antibody to detect R1 (RgpA), its presence PD population. To further elucidate action this gingipain, as well lipopolysaccharide (LPS) P. gingivalis, low concentrations recombinant RgpA LPS were added purified fibrinogen. We also substantiate previous findings regarding by emphasizing inflammation via multiplex cytokine analysis, demonstrate hypercoagulation thromboelastography (TEG), confocal electron microscopy. Biomarker analysis confirmed significantly increased levels circulating proinflammatory cytokines. In our control blood results show hypercoagulation, amyloid formation plasma, profound ultrastructural changes platelets. Our laboratory fibrinogen RgpA, and/or LPS, showed preliminary data regards actions bacterial membrane inflammagen on plasma proteins, better understand nature PD.