The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma

摘要: The human T-cell leukemia/lymphoma virus (HTLV) is a novel type-C retrovirus isolated from patients with Tlymphoproliferative malignancies. Thirteen cases of HTLVassociated malignancy US centers were studied in detail. Ten these share common clinical features and define typical virus-associated adult leukemia! lymphoma (ATI). All ten presented Ann Arbor stage IV because skin involvement. bone marrow or lymphomatous leptomeningitis. Lymphadenopathy occurred 7 10 at presentation. the malignant cells cytologically pleomorphic. Leukemia 60% Hypercalcemia was found initially twoT HE UNIQUE RETROVIRUS, (HTLV), first isolated, identified, characterized patient cutaneous lymphoma.’ HTLV distinct other viruses animal retroviruses by studies its nucleic acids,2 major core proteins p243 p19,4 reverse transcriptase.5 Seroepidemiologic 1 98 demonstrated that associated previously described entity, leukemia (ATL) ofiapan.6 Later, Catovsky et al. reported cluster T-lymphosarcoma cell (LCL) Caribbean blacks7 shown to be associated.8 Subsequently, three additional lymphoma, hypercalcemia, lesions, antibodies reported.9 In later serologic surveys, syndrome has emerged as “sentinel disease” for association HTLV. We describe HTLV-associated ascertained during disease-oriented seroepidemiologic survey treated institutions. Patients who had specific serum disrupted viral particles (and most protein p24) qualified inclusion into study. characteristic pathologic disease (CTCL), are shared patients. apparently unusual US, where only one endemic focus been tentatively identified.’#{176}