Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma

摘要: BACKGROUND The association between dietary folate intake, two polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS), survival head neck squamous cell carcinoma (HNSCC) patients is not clarified. PATIENTS AND METHODS We conducted a retrospective cohort study of 437 HNSCC treated at Aichi Cancer Center. evaluated the impact pretreatment which was estimated using food-frequency questionnaire, polymorphisms, MTHFR C677T 6-bp insertion/deletion 3'-untranslated region TYMS, multivariate proportional hazard models. RESULTS Patients with high intake (≥320 μg/day; n=144) had significantly higher than low or medium (<320 n=278; 79.1% versus 68.2%, respectively, P=0.020). This consistent analyses adjusted for established prognostic factors (hazard ratio 0.56; 95% confidence interval 0.37-0.84). TYMS did show significant survival, although insertion allele showed potential reduced risk death. Notably, no interaction observed examined polymorphisms. CONCLUSIONS High identified as an independent factor associated improved clinical outcomes patients. Further warranted.