Advances in the genetics of glioblastoma: are we reaching critical mass?

摘要: Glioblastoma is the most common and highest-grade brain tumor, causing over 10,000 deaths each year in US alone. Given resistance of this tumor to standard surgery, radiation chemotherapy, an understanding underlying genetic lesions vital. Recent efforts comprehensively profile glioblastomas using latest technologies, both by The Cancer Genome Atlas (TCGA) project other groups, are addressing need. Some aberrations glioblastoma have been known for decades, but early output from new profiling initiatives has further illuminated relevant genetics disease. lesions, such as TP53 mutation, NF1 deletion or ERBB2 amplification, found be more than was previously reported. New unexpected discoveries also made, frequent mutations IDH1 IDH2 genes secondary glioblastoma. We might tempted speculate that we approaching a comprehensive knowledge involved glioblastoma, although major doubtless remain made. In addition, complex task incorporating our updated into new—and possibly personalized—therapies patients with still lies ahead.