The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility

摘要: The adult neural parenchyma contains a distinctive extracellular matrix that acts as barrier to cell and neurite motility. Nonneural tumors metastasize the central nervous system almost never infiltrate it instead displace tissue they grow. In contrast, invasive gliomas disrupt disperse within tissue. A major inhibitory component of is lectican family chondroitin sulfate proteoglycans, which brevican most abundant member in brain. Interestingly, also highly up-regulated promotes glioma dispersion by unknown mechanisms. Here we show secreted cells enhances adhesion motility only after proteolytic cleavage. At molecular level, epidermal growth factor receptor activation, increases expression molecules, secretion fibronectin accumulation microfibrils on surface. Moreover, N-terminal cleavage product brevican, but not full-length protein, associates with cultured surgical samples glioma. Taken together, our results provide first evidence cellular mechanisms may underlie motility-promoting role primary brain tumors. addition, these underscore important functional implications processing progression.