Somatic Mutations ofEGFRin Colorectal Cancers and Glioblastomas

摘要: To the Editor: Recent reports suggest that mutations in epidermal growth factor receptor (EGFR) gene predict sensitivity to EGFR kinase inhibitors. In particular, patients with lung cancers containing domain have had responses gefitinib.1,2 Are similar present a significant fraction of other tumor types for which gefitinib might be suitable therapy? answer this question, we screened DNA from 293 colorectal tumors and 59 glioblastomas alterations (exons 17 24). These were chosen analysis because they been linked . . .