Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system.

摘要: BACKGROUND An epidermal growth factor receptor (EGFR) immunohistochemical detection system currently is being developed. The current study attempts to address background EGFR reactivity issues before determining the optimum scoring system. METHODS Tissue sections from 102 patients with T3N1-2M1 colon adenocarcinoma were stained a prototype system. number of cases, location, percentage, and intensity reactive cells (0+ [none] 3+ [strong]) scored compared length survival. RESULTS Approximately 75.5% cases had reactivity; 31.4% tumors in 10–50% neoplastic 3.9% > 50% cells. Increased numbers per case predominantly resulted increased reactivity. mean percentage 2+ (moderate) regions deepest invasion. was significantly greater tumor region superficial (16.9% vs. 7.9%; P = 0.004). metastases appeared have strongest correlation deep adenocarcinoma. An increasing or only found decreased survival (P 0.0252). CONCLUSIONS EGFR may provide framework for It be important evaluate invasion because this appears contain largest lymph node liver metastases. Cancer 2001;92:1331–46. © 2001 American Society.