The p53 pathway
作者： Carol Prives , Peter A. Hall
DOI: 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3
关键词:
摘要: Abnormalities of the p53 tumour suppressor gene are among most frequent molecular events in human and animal neoplasia. Moreover, is one studied proteins whole contemporary biology, with more than 12,500 papers so far written! In this review choice has been deliberately made not to be fully comprehensive coverage huge literature. Rather attention focused on a small number recent developments which reviewed context modern models function. Progress analysis signalling including phosphorylation cascades, interactions such as mdm2 ARF highlighted. The plethora protein-protein discussed, strategies for defining downstream targets p53. Finally, emerging biology homologues considered. need bridging gap between reductionist, biochemical biophysical studies biological genetic emphasized. Only will provide needed framework utilizing information clinical care.
sci-hub.se 参考文章(151)
L L Nielsen, D C Maneval, P53 tumor suppressor gene therapy for cancer. Cancer Gene Therapy. ,vol. 5, pp. 52- 63 ,(1998)
P. Lassus, M. Ferlin, J. Piette, U. Hibner, Anti-apoptotic activity of low levels of wild-type p53 The EMBO Journal. ,vol. 15, pp. 4566- 4573 ,(1996) , 10.1002/J.1460-2075.1996.TB00834.X
Pellegata Ns, Stanbridge Ej, Cajot Jf, The basic carboxy-terminal domain of human p53 is dispensable for both transcriptional regulation and inhibition of tumor cell growth. Oncogene. ,vol. 11, pp. 337- 349 ,(1995)
D W Meek, Post-translational modification of p53. Seminars in Cancer Biology. ,vol. 5, pp. 203- 210 ,(1994)
D. W. Meek, S. Simon, U. Kikkawa, W. Eckhart, The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II. The EMBO Journal. ,vol. 9, pp. 3253- 3260 ,(1990) , 10.1002/J.1460-2075.1990.TB07524.X
T.D. Halazonetis, L.J. Davis, A.N. Kandil, Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA. The EMBO Journal. ,vol. 12, pp. 1021- 1028 ,(1993) , 10.1002/J.1460-2075.1993.TB05743.X
D. J. O'Connor, E. W. Lam, S. Griffin, S. Zhong, L. C. Leighton, S. A. Burbidge, X. Lu, Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. The EMBO Journal. ,vol. 14, pp. 6184- 6192 ,(1995) , 10.1002/J.1460-2075.1995.TB00309.X
J. Milner, A. Cook, J. Mason, p53 is associated with p34cdc2 in transformed cells. The EMBO Journal. ,vol. 9, pp. 2885- 2889 ,(1990) , 10.1002/J.1460-2075.1990.TB07478.X
Matthew J. F. Waterman, Elena S. Stavridi, Jennifer L. F. Waterman, Thanos D. Halazonetis, ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins Nature Genetics. ,vol. 19, pp. 175- 178 ,(1998) , 10.1038/542
Richard A. Woo, Kevin G. McLure, Susan P. Lees-Miller, Derrick E. Rancourt, Patrick W. K. Lee, DNA-dependent protein kinase acts upstream of p53 in response to DNA damage Nature. ,vol. 394, pp. 700- 704 ,(1998) , 10.1038/29343