Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers

摘要: The RAS-MAPK, PI (3)K signaling pathways form a network that play central role in tumorigenesis. BRAF, KRAS and PI3KCA genes code 3 partners of this have been found to be activated by mutation colorectal cancer; these mutations lead unrestricted cell growth. We evaluated the clinicopathological features prognosis patients with activated-network colon cancers population-based study. A total 586 adenocarcinomas were using sequencing for PI3KCA, allelic discrimination BRAF. Clinicopathological characteristics correlated risk bearing logistic regression. Three-year survival rates compared Log rank test. multivariate analysis Cox model was performed. After adjustment age microsatellite instability, activation at least 1 significantly associated female sex (p = 0.02) proximal location < 0.001). Lower levels 3-year (59.4 69.4%, respectively; p 0.009). These results remained significant adjusted sex, age, location, stage instability (HR 1.48; CI CI(95%) [1.07-2.04]). Our study is first report underline potential on cancers. Because anticancer agents, evaluation its could clinical implications.