HER2 (c-erbB-2) oncoprotein expression in colorectal adenocarcinoma: an immunohistological study using three different antibodies.

摘要: Paraffin wax sections of 70 surgically resected colorectal adenocarcinomas were examined for the overexpression HER2/c-erbB-2 oncoprotein using three different specific antibodies and avidin-biotin immunoperoxidase technique. The patients included 38 men 32 women aged between 47 80 years. tumours derived from various parts large intestinal tract, represented all stages Dukes' classification histological grades differentiation. Many tumour also adjacent normal or transitional mucosa. Eight tubular adenomas found in colectomy specimens association with some carcinomas examined. No positive membrane staining was seen any carcinomas, four adenomas, two hyperplastic polyps, nor It is suggested that c-erbB-2 gene product unlikely to be as common pronounced adenocarcinoma it ductal carcinoma breast.