Racial differences in oncogene mutations detected in early-stage low-grade endometrial cancers.

摘要: Objective To describe the pattern and frequency of oncogene mutations in white African American women with endometrial cancer to determine if racial differences exist among pathologically similar tumors. Methods Patients from a large urban hospital were identified through medical records, representative formalin-fixed paraffin-embedded tumor blocks retrieved. The study sample included 150 patients (84 Americans) who underwent total abdominal hysterectomy for cancer. Sequenom MassARRAY system OncoCarta Assay version 1.0 (Sequenom) used test 238 19 common oncogenes. χ2 Fisher exact assess distribution variables by race mutation status. Results There 20 2 oncogenes (PIK3CA KRAS) tumors (12.7%). Most found PIK3CA (16/20). Thirteen percent endometrioid harbored (11 as did 29% malignant mixed Mullerian (3 1 KRAS). no observed serous, clear cell, or mucinous types. Among low-grade cancers, significantly associated harboring either KRAS (P = 0.04), 7 all 4 women. Conclusions This provides preliminary evidence that some subtypes histologically carcinoma differ race. Additional studies are needed further explore this phenomenon carcinoma.