Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter “RASCAL” Study

摘要: Background: Kirsten ras (Ki-ras) gene mutations occur early in the progression of colorectal adenoma to carcinoma. The aim this collaborative study was clarify association between Ki-ras mutations, patient outcome, and tumor characteristics by use data from cancer patients worldwide. Methods: Investigators who had published on were invited complete a questionnaire for each entered into database. Twosided statistical tests used analyze data. Results: Patients (n = 2721) recruited 22 groups 13 countries. Mutations codon 12 (wild type GGT glycine) or GGC detected 37.7% tumors; 80.8% (584 723) all specified occurred 12, 78.1% (565 at second base either codon. not associated with sex, age, site, Dukes’ stage. Mutation rates seen sporadic tumors comparable those observed predisposing cause their cancer. Poorly differentiated less frequently mutated (P .002). Multivariate analysis suggested that presence mutation increased risk recurrence (P<.001) death .004). In particular, any guanine (G) thymine (T) but adenine (A) cytosine (C) .006) (P<.001). When individual, specific evaluated, only valine found convey an independent, .007) Conclusions: are relapse death, some more aggressive than others. [J Natl Cancer Inst 1998;90:675‐84]